Johnson J D, Epel D
Nature. 1976 Aug 19;262(5570):661-4. doi: 10.1038/262661a0.
The intracellular pH of the sea urchin embryo increases 0.3 pH units between 1 and 4 min after fertilisation. The increase in pH is required for initiating development. The increase results from an exchange of extracellular Na+ for intracellular H+.