Zangheri E O
Exp Hematol. 1977 May;5(3):211-4.
Erythropoietin production was studied in 30-day-old and adult rats previously injected with pharmacological doses of isoproterenol. The animals were stimulated either by hypobaric hypoxia or by a combination of hypoxia and acute anemia. The erythropoietic activity of the plasma was measured by 59Fe incorporation in total circulating red blood cells of mice made polycythemic by chronic hypoxia. The results were converted to units of erythropoietin (IRP). A significant reduction of erythropoietin production was observed only in young rats. Our interpretation of the findings is that isoproterenol induced the differentiation of the salivary glands in the young animals hence reducing hormone production at the extrarenal (submandibular) level.
对先前注射过药理剂量异丙肾上腺素的30日龄和成年大鼠的促红细胞生成素生成情况进行了研究。通过低压缺氧或缺氧与急性贫血相结合的方式刺激这些动物。通过将59Fe掺入经慢性缺氧造成红细胞增多的小鼠的总循环红细胞中来测量血浆的促红细胞生成活性。结果换算为促红细胞生成素单位（国际参考制剂）。仅在幼鼠中观察到促红细胞生成素生成显著减少。我们对这些发现的解释是，异丙肾上腺素诱导了幼龄动物唾液腺的分化，从而降低了肾外（下颌下）水平的激素生成。
