缺水大鼠红细胞生成减少的机制

Mechanism of the decreased erythropoiesis in the water deprived rat.

作者信息

Giglio J M, Alippi R M, Barceló A C, Bozzini C E

出版信息

Br J Haematol. 1979 May;42(1):93-9. doi: 10.1111/j.1365-2141.1979.tb03701.x.

DOI:10.1111/j.1365-2141.1979.tb03701.x

Abstract

Radioiron uptake by erythrocytes, metabolic rate, erythropoietin formation during hypoxia and erythroid responsiveness to exogenous erythropoietin were determined in both starved and water deprived rats. The feed intake showed a marked and progressive reduction during water deprivation. The metabolic rates of rats deprived of either food of water declined progressively showing a 40% reduction 5d after water deprivation or starvation began. At this time, the 24 h red blood cells 59Fe incorporation was 85% lower in both starved and dehydrated rats than in normal rats. Plasma erythropoietin levels in response to hypoxia were approximately 50% decreased in both starved and dehydrated rats. Both polycythaemic starved and polycythaemic water deprived rats injected with human urinary erythropoietin showed a 75% decrease in 59Fe incorporation into erythrocytes when compared to control rats. It is suggested that depression of erythropoiesis during water deprivation in the rat depends on a reduced sensitivity to erythropoietin, possibly associated with decreased production of the hormone. Since water deprived rats drastically reduce feed intake it is suggested that secondary starvation is the principal cause of the decreased erythropoiesis induced in the rat by water deprivation.

摘要

对饥饿和缺水大鼠的红细胞对放射性铁的摄取、代谢率、缺氧时促红细胞生成素的形成以及红系对外源性促红细胞生成素的反应性进行了测定。缺水期间，采食量显著且逐渐减少。无论缺水还是饥饿，大鼠的代谢率均逐渐下降，在缺水或饥饿开始5天后降低40%。此时，饥饿和脱水大鼠24小时红细胞对59Fe的摄取量比正常大鼠低85%。饥饿和脱水大鼠缺氧时血浆促红细胞生成素水平均降低约50%。与对照大鼠相比，注射人尿促红细胞生成素的红细胞增多症饥饿大鼠和红细胞增多症缺水大鼠红细胞对59Fe的摄取量均降低75%。提示大鼠缺水期间红细胞生成受抑制取决于对促红细胞生成素敏感性降低，可能与该激素生成减少有关。由于缺水大鼠采食量大幅减少，提示继发性饥饿是缺水诱导大鼠红细胞生成减少的主要原因。