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[心房颤动的非药物治疗]

[Non-pharmacological treatment of atrial fibrillation].

作者信息

Kirkorian G

机构信息

Hôpital cardiovasculaire et pneumologique Louis-Pradel, Lyon.

出版信息

Arch Mal Coeur Vaiss. 1995 Dec;88 Spec No 5:49-54.

PMID:8729300
Abstract

Although often denigrated in recent years, antiarrhythmic drugs frequently enable control of atrial fibrillation in patients who are symptomatic or at high risk of complications. In patients resistant to therapy, a number of non-pharmacological options have become available. The choice is no longer limited to his bundle ablation, a method previously at the point of progress but which has gradually given way to more sophisticated and less definitively destructive techniques. Modulation of atrioventricular conduction is currently under development, the feasibility of which has not yet been completely evaluated, but whichmay provide a less radical alternative in selected patients. Restoration of sinus rhythm by electrical cardioversion has benefitted from the advances of cardiac defibrillation in general. The theoretical information which its use implies has improved its efficacy, especially in the case of endocavitary electrical shock. This method can also be employed with automatic implantable defibrillators but using specific algorithms. Atrial pacing is credited with a preventive efficacy but this has never been definitely demonstrated. Research is under way in this domain. Future hopes are also centered on atrial surgery, especially the operation described by Cox which is generally accepted to be effective and which may be adapted medically using endocavitary radiofrequency current. Most of these methods are insufficiently experimented but they should be considered reasonably in particularly symptomatic patients duely informed of the nature of the treatments which are proposed.

摘要

尽管近年来抗心律失常药物常常受到诋毁,但对于有症状或有高并发症风险的患者,抗心律失常药物常常能够控制房颤。对于治疗抵抗的患者,已有多种非药物治疗选择。选择不再局限于希氏束消融,这种方法以前处于进展阶段,但已逐渐被更复杂、破坏性更小的技术所取代。房室传导调节目前正在研发中,其可行性尚未得到完全评估,但在特定患者中可能提供一种不那么激进的替代方法。电复律恢复窦性心律总体上受益于心脏除颤技术的进步。其使用所隐含的理论知识提高了其疗效,尤其是在心腔内电击的情况下。这种方法也可与自动植入式除颤器一起使用,但要使用特定算法。心房起搏被认为具有预防效果,但从未得到明确证实。该领域的研究正在进行中。未来的希望也集中在心房手术上,尤其是考克斯描述的手术,该手术通常被认为是有效的,并且可以通过心腔内射频电流进行医学调整。这些方法大多没有经过充分试验,但对于特别有症状的患者,在充分告知所提议治疗性质的情况下,应合理考虑这些方法。

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