Deng L H, Barbenel J C, Lowe G D
Bioengineering Unit, University of Strathclyde, Glasgow, UK.
Biorheology. 1994 Mar-Apr;31(2):193-205. doi: 10.3233/bir-1994-31207.
The influence of hematocrit on red blood cell aggregation was investigated using a modified automated Myrenne Aggregometer System. Hematocrit values ranged from 20-70% at 10% increments, and were produced by resuspending washed red cells in autologous plasma. The Myrenne System produced seven kinetic parameters of red cell aggregation. The results indicate that hematocrit (Hct) had a strong and nonlinear effect on erythrocyte aggregability. At both low and high hematocrit, the aggregation intensity (AI) tends to decrease, reaching a plateau at 40% hematocrit. The disaggregation shear rate demonstrates an exponential relationship as In gamma TMIN = 3.29-0.0837 Hct. Time constants of the aggregation process such as T1/2, TSLOW and TFAST were rather inconsistent. The increase of hematocrit increased the rate of the fast phase aggregation and slightly slowed the secondary aggregation.
使用改良的自动Myrenne血细胞聚集仪系统研究了血细胞比容对红细胞聚集的影响。血细胞比容值以10%的增量在20%-70%范围内，通过将洗涤后的红细胞重悬于自体血浆中来产生。Myrenne系统产生了七个红细胞聚集动力学参数。结果表明，血细胞比容（Hct）对红细胞聚集性有强烈的非线性影响。在低血细胞比容和高血细胞比容时，聚集强度（AI）均趋于降低，在血细胞比容为40%时达到平稳状态。解聚切变率呈现指数关系，即InγTMIN = 3.29 - 0.0837Hct。聚集过程的时间常数如T1/2、TSLOW和TFAST相当不一致。血细胞比容的增加提高了快速相聚集的速率，并使二次聚集略有减慢。
