系统性硬化症患者的24小时心率变异性

Twenty-four hour heart period variability in systemic sclerosis.

作者信息

Morelli S, Piccirillo G, Fimognari F, Sgreccia A, Ferrante L, Morabito G, De Marzio P, Valesini G, Marigliano V

机构信息

Istituto di I Clinica Medica, University La Sapienza, Rome, Italy.

出版信息

J Rheumatol. 1996 Apr;23(4):643-5.

PMID:8730119

Abstract

OBJECTIVE

In patients with systemic sclerosis (SSc), an autonomic dysfunction has been implicated in the pathogenesis of Raynaud's phenomenon and gastrointestinal symptoms. To evaluate cardiovascular autonomic function we analyzed the heart rate variability (HRV) on 24 h electrocardiogram recordings.

METHODS

In 50 patients diagnosed with SSc and 24 control subjects HRV was analyzed for both frequency and time domain.

RESULTS

Frequency domain analysis showed reduction of low frequency and high frequency values in the patients with SSc compared to controls (5.52 +/- 0.74 vs 6.04 +/- 0.78 In(ms2), p = 0.007; and 4.17 +/- 0.97 vs 4.74 +/- 0.97 In(ms2), p = 0.021, respectively). Analysis in time domain showed no significant differences in any variable between groups. There were no significant differences between the diffuse and the limited form of SSc. Number of ventricular ectopic beats, prevalence of frequent ventricular ectopy, and supraventricular tachycardia episodes were increased in the patients with SSc compared to controls.

CONCLUSION

Spectral analysis of heart period variability suggests cardiovascular autonomic dysfunction in patients with SSc. Better understanding of this complication could help delineate new strategies for the treatment of SSc.

摘要

目的

在系统性硬化症（SSc）患者中，自主神经功能障碍与雷诺现象和胃肠道症状的发病机制有关。为评估心血管自主神经功能，我们分析了24小时心电图记录中的心率变异性（HRV）。

方法

对50例诊断为SSc的患者和24例对照者的HRV进行频域和时域分析。

结果

频域分析显示，与对照组相比，SSc患者的低频和高频值降低（分别为5.52±0.74对6.04±0.78ln(ms2)，p = 0.007；以及4.17±0.97对4.74±0.97ln(ms2)，p = 0.021）。时域分析显示两组之间任何变量均无显著差异。SSc的弥漫型和局限型之间无显著差异。与对照组相比，SSc患者的室性早搏数量、频发室性早搏患病率和室上性心动过速发作次数增加。