计算机断层扫描引导下对患有骶髂关节炎的脊柱关节病患者进行骶髂关节皮质类固醇注射:临床结果及动态磁共振成像随访
Computed tomography guided corticosteroid injection of the sacroiliac joint in patients with spondyloarthropathy with sacroiliitis: clinical outcome and followup by dynamic magnetic resonance imaging.
作者信息
Braun J, Bollow M, Seyrekbasan F, Häberle H J, Eggens U, Mertz A, Distler A, Sieper J
机构信息
Abteilung für Allgemeine Innere Medizin und Nephrologie, Klinikum Benjamin Franklin, Freie Universität Berlin, Germany.
出版信息
J Rheumatol. 1996 Apr;23(4):659-64.
OBJECTIVE
To evaluate computed tomography (CT) guided corticosteroid injections of inflamed sacroiliac (SI) joints in patients with spondyloarthropathies (SpA), and to evaluate dynamic magnetic resonance imaging (DMRI) of the SI joints in serial examinations of these patients, who had different degrees of inflammatory back pain.
METHODS
We examined and treated 30 patients with ankylosing spondylitis (n = 9) or undifferentiated SpA (n = 11) (14 women and 16 men, mean age 36.5 +/- 13.4 years, mean disease duration 5.4 +/- 4.0 years) who had severe inflammatory back pain for more than 3 months. All patients had DMRI of the SI joints before and 4-6 months after a CT guided injection of 40 mg triamcinolone acetonide into SI joints (n = 54; 24 patients received injections in both joints). Enhancement of the contrast agent gadolinium-DTPA was quantified by calculating the enhancement of the contrast agent gadolinium-DTPA was quantified by calculating the enhancement gradient Fenh. A subjective index with a visual analog scale (0 = no pain, 10 = very severe pain) was used for assessment of back pain. Followup visits were done every 3 months for a maximum of 18 months.
RESULTS
There was significant improvement of inflammatory back pain and sacroiliitis at 5.2 +/- 1.3 months after therapy in 25/30 patients (83.3%). The differences between the Fenh values before (98.2 +/ 56.1) and after (44.3 +/- 31.2) therapy and of the subjective pain index (8.5 +/- 1.5 and 3.0 +/- 2.3, respectively) were statistically significant. Subjective improvement lasted a mean of 8.9 +/- 5.3 months.
CONCLUSION
CT guided corticosteroid injection of inflamed SI joints is a useful option in therapy for sacroiliitis in patients with SpA. Different degrees of inflammation in the SI joints can be quantitatively assessed by DMRI.
目的
评估计算机断层扫描(CT)引导下对脊柱关节病(SpA)患者发炎的骶髂关节(SI)进行皮质类固醇注射的效果,并在对这些有不同程度炎性背痛的患者进行系列检查时评估SI关节的动态磁共振成像(DMRI)。
方法
我们检查并治疗了30例患有强直性脊柱炎(n = 9)或未分化SpA(n = 11)的患者(14名女性和16名男性,平均年龄36.5 +/- 13.4岁,平均病程5.4 +/- 4.0年),他们有严重炎性背痛超过3个月。所有患者在CT引导下向SI关节注射40mg曲安奈德之前及之后4 - 6个月均进行了SI关节的DMRI检查(n = 54;24例患者双侧关节均接受了注射)。通过计算钆 - DTPA造影剂的增强梯度Fenh对钆 - DTPA造影剂的增强进行定量。使用视觉模拟量表主观指标(0 =无疼痛,10 =非常严重疼痛)评估背痛。每3个月进行一次随访,最长随访18个月。
结果
25/30例患者(83.3%)在治疗后5.2 +/- 1.3个月时炎性背痛和骶髂关节炎有显著改善。治疗前(98.2 +/ 56.1)和治疗后(44.3 +/- 31.2)的Fenh值差异以及主观疼痛指标差异(分别为8.5 +/- 1.5和3.0 +/- 2.3)具有统计学意义。主观改善平均持续8.9 +/- 5.3个月。
结论
CT引导下对发炎的SI关节进行皮质类固醇注射是SpA患者骶髂关节炎治疗中的一种有用选择。DMRI可对SI关节不同程度的炎症进行定量评估。