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CT引导下骶髂关节皮质类固醇注射:质量保证及对六个月以上长期疗效的标准化前瞻性评估

CT-guided corticosteroid injection of the sacroiliac joints: quality assurance and standardized prospective evaluation of long-term effectiveness over six months.

作者信息

Althoff Christian E, Bollow Matthias, Feist Eugen, Marticorena-Garcia Stephan R, Eshed Iris, Diekhoff Torsten, Hamm Bernd, Hermann Kay Geert A

机构信息

Department of Radiology, Charité Medical University, Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany.

出版信息

Clin Rheumatol. 2015 Jun;34(6):1079-84. doi: 10.1007/s10067-015-2937-7. Epub 2015 Apr 22.

DOI:10.1007/s10067-015-2937-7
PMID:25896531
Abstract

Steroid injection of the sacroiliac joints is widely used for the management of active sacroiliitis in patients with spondyloarthritis (SpA). The aims of this study were to prospectively investigate the effectiveness of corticosteroid injection of the sacroiliac joints and to identify factors determining positive and negative outcome. Twenty-nine patients (18 female, 11 male) suffering from sacroiliitis were treated by computed tomography (CT)-guided administration of 40 or 60 mg triamcinolone acetonide per joint. Clinical outcome of the intervention was determined using a visual analog scale from days 1 to 7 as well as after 1, 3, and 6 months. Patients were grouped according to intra-articular (n = 22) and peri-articular positions (n = 7) of the tip of the puncture needle. In patients with intra-articular needle position (76 %), the mean pain score decreased significantly from 7.3 (±1.9) to 3.9 (±3.4) at day 7 and to 3.9 (±3.4) after 1 month, 4.2 (±3.3) after 3 months, and 5.2 (±2.9) after 6 months. The group with peri-articular needle position (24 %) did not show a statistically significant pain reduction throughout the entire 6-month follow-up period. A substantial reduction of inflammatory back pain (reduction of at least 4 visual analog scale (VAS) points) was reported by 55 % of patients after 3 months and 45 % of patients after 6 months. Our results demonstrate that intra-articular CT-guided steroid instillation can achieve sufficient pain and symptom control for 6 months in patients suffering from active sacroiliitis. It is therefore recommended to perform this intervention under appropriate image guidance to ensure proper positioning of the needle tip.

摘要

骶髂关节注射类固醇广泛用于治疗脊柱关节炎(SpA)患者的活动性骶髂关节炎。本研究的目的是前瞻性地研究骶髂关节注射皮质类固醇的有效性,并确定决定阳性和阴性结果的因素。29例患有骶髂关节炎的患者(18例女性,11例男性)接受了计算机断层扫描(CT)引导下每个关节注射40或60mg曲安奈德的治疗。使用视觉模拟量表在第1至7天以及1、3和6个月后确定干预的临床结果。根据穿刺针尖端的关节内(n = 22)和关节周围位置(n = 7)对患者进行分组。在关节内针位的患者(76%)中,平均疼痛评分在第7天从7.3(±1.9)显著降至3.9(±3.4),1个月后降至3.9(±3.4),3个月后降至4.2(±3.3),6个月后降至5.2(±2.9)。关节周围针位的组(24%)在整个6个月的随访期内未显示出统计学上显著的疼痛减轻。3个月后,55%的患者报告炎性背痛大幅减轻(视觉模拟量表(VAS)至少降低4分),6个月后为45%。我们的结果表明,CT引导下关节内注射类固醇可为活动性骶髂关节炎患者实现6个月的充分疼痛和症状控制。因此,建议在适当的影像引导下进行这种干预,以确保针尖的正确定位。

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