Krishnaswamy G, Odem C, Chi D S, Kalbfleisch J, Baker N, Smith J K
Department of Medicine, East Tennessee State University, James H. Quillen College of Medicine, Johnson City 37614-0622, USA.
J Rheumatol. 1996 Apr;23(4):763-5.
Felty's syndrome is characterized by neutropenia, splenomegaly, and recurrent infection in patients with rheumatoid arthritis. We used recombinant granulocyte colony stimulating factor (rGCSF) in a patient with Felty's syndrome and recurrent sepsis. rGCSF induced a statistically significant increase in the patient's absolute neutrophil and total white blood cell counts. During 14 months of followup taking rGCSF, disseminated varicella zoster was the only infectious complication. Except mild thrombocytopenia and a transient flare of arthritis, no serious adverse effects occurred. rGCSF may be a safe and effective therapy for Felty's syndrome in selected patients.
费尔蒂综合征的特征是类风湿关节炎患者出现中性粒细胞减少、脾肿大和反复感染。我们对一名患有费尔蒂综合征并反复发生败血症的患者使用了重组粒细胞集落刺激因子（rGCSF）。rGCSF使患者的绝对中性粒细胞计数和总白细胞计数出现了具有统计学意义的增加。在接受rGCSF治疗的14个月随访期间，播散性水痘带状疱疹是唯一的感染性并发症。除了轻度血小板减少和关节炎短暂发作外，未出现严重不良反应。对于部分选定的患者，rGCSF可能是治疗费尔蒂综合征的一种安全有效的疗法。
