Ishikawa Keiko, Tsukada Yoshito, Tamura Shigeo, Kaneko Yoriaki, Kuroiwa Takashi, Ueki Kazue, Sugiura Tomoko, Nojima Yoshihisa
Third Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
J Rheumatol. 2003 Feb;30(2):404-6.
Felty's syndrome is characterized by neutropenia, splenomegaly, and leg ulcers in patients with rheumatoid arthritis. The pathogenesis of the neutropenia is an immune-mediated process that involves immune complexes, antineutrophil antibodies, and abnormal white cell kinetics. We prescribed salazosulfapyridine to a 65-year-old woman with this syndrome. The neutropenia improved along with a reduction in neutrophil-bound IgG, demonstrated by flow cytometric analysis. Salazosulfapyridine may be of benefit for the treatment of Felty's syndrome, and flow cytometry can be used to monitor disease activity and therapeutic efficacy.
费尔蒂综合征的特征是类风湿关节炎患者出现中性粒细胞减少、脾肿大和腿部溃疡。中性粒细胞减少的发病机制是一个免疫介导的过程，涉及免疫复合物、抗中性粒细胞抗体和异常的白细胞动力学。我们给一位患有该综合征的65岁女性开了柳氮磺胺吡啶。中性粒细胞减少症有所改善，同时通过流式细胞术分析显示中性粒细胞结合的IgG减少。柳氮磺胺吡啶可能对治疗费尔蒂综合征有益，并且流式细胞术可用于监测疾病活动和治疗效果。
