Mok C C, Lau C S
Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong.
J Rheumatol. 1996 Apr;23(4):766-8.
Dapsone is increasingly used in the treatment of rheumatic diseases. It is indicated in many inflammatory skin conditions characterized by polymorphonuclear cell infiltration. Minor reactions to the drug are very common, but severe idiosyncratic reactions are rare considering the large number of patients taking this drug worldwide. We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one. Physicians should be aware of the potentially lethal side effects of dapsone.
氨苯砜越来越多地用于治疗风湿性疾病。它适用于许多以多形核细胞浸润为特征的炎症性皮肤病。该药物的轻微反应非常常见，但考虑到全球服用此药的患者数量众多，严重的特异质性反应却很少见。我们描述了2例皮肤红斑狼疮患者，他们在低剂量治疗后出现了严重的氨苯砜反应，其中1例死亡。医生应意识到氨苯砜可能存在的致命副作用。
