Malec E, Malec T, Gagné M A, Dongier M
Douglas Hospital Research Center, Alcohol Research Program, Montreal, Quebec, Canada.
Alcohol Clin Exp Res. 1996 Apr;20(2):307-12. doi: 10.1111/j.1530-0277.1996.tb01644.x.
A double-blind controlled study of the effects of buspirone on alcohol dependence and associated symptoms in ambulatory alcoholics showed a marked improvement in both treatment and control groups. However, significant differences in favor of the medication were observed in several psychopathological measures, but not in measures of alcohol consumption. Contrary to a majority of prior controlled trials of buspirone in alcoholics, subjects were not selected on the basis of comorbid generalized anxiety; rather, the study tested the hypothesis of a direct effect on craving and consumption, independent from an anxiolytic effect. This hypothesis was not confirmed.
一项关于丁螺环酮对非住院酗酒者酒精依赖及相关症状影响的双盲对照研究显示，治疗组和对照组均有显著改善。然而，在几项精神病理学指标上观察到有利于该药物的显著差异，但在酒精摄入量指标上未观察到。与之前大多数针对酗酒者的丁螺环酮对照试验不同，该研究并非基于共病广泛性焦虑来选择受试者；相反，该研究检验了丁螺环酮对渴望和饮酒量有直接影响（独立于抗焦虑作用）这一假设。这一假设未得到证实。
