Tollefson G D, Montague-Clouse J, Tollefson S L
Department of Psychiatry, Ramsey Clinic, St. Paul, Minnesota.
J Clin Psychopharmacol. 1992 Feb;12(1):19-26. doi: 10.1097/00001573-199202000-00004.
Recent literature has addressed a common dyad: alcoholism and anxiety. Both disorders have been interdigitated with the brain amine serotonin. We investigated 51 dually diagnosed patients (generalized anxiety/alcohol abuse:dependence) in a randomized, double-blind, placebo-controlled trial of the serotonin partial agonist buspirone. Buspirone was superior to placebo as an anxiolytic, was well tolerated, and was associated with both a reduction in the number of days desiring alcohol and an overall clinical global improvement.
酗酒和焦虑。这两种病症都与脑胺血清素相互关联。我们在一项针对血清素部分激动剂丁螺环酮的随机、双盲、安慰剂对照试验中，对51名双重诊断患者（广泛性焦虑/酒精滥用：依赖）进行了研究。丁螺环酮作为一种抗焦虑药优于安慰剂，耐受性良好，并且与渴望饮酒天数的减少以及整体临床综合改善相关。
