Foy C A, McCormack L J, Knowler W C, Barrett J H, Catto A, Grant P J
Department of Clinical Medicine, University of Leeds, UK.
J Med Genet. 1996 Apr;33(4):336-7. doi: 10.1136/jmg.33.4.336.
An insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene is associated with plasma ACE levels in white populations. The occurrence of the I/D polymorphism and relationship to ACE levels was examined in a Pima Indian group (n = 305). The frequency of the D allele was lower in Pimas than whites (0.29 v 0.52 respectively). ACE levels were significantly associated with genotype in both groups (p = 0.0001), which accounted for 6.5% of the variation in ACE levels in Pimas and 18% in whites. The association of the I/D polymorphism with ACE levels confirms the relationship across ethnic groups. The low frequency of the D allele in Pima Indians shows that ethnic differences should be accounted for when studying the ACE gene.
血管紧张素转换酶（ACE）基因的插入/缺失（I/D）多态性与白种人群的血浆ACE水平相关。在皮马印第安人群体（n = 305）中检测了I/D多态性的发生情况及其与ACE水平的关系。皮马人D等位基因的频率低于白人（分别为0.29和0.52）。两组中ACE水平均与基因型显著相关（p = 0.0001），该因素在皮马人ACE水平变异中占6.5%，在白人中占18%。I/D多态性与ACE水平的关联证实了不同种族之间的这种关系。皮马印第安人D等位基因的低频率表明，在研究ACE基因时应考虑种族差异。
