Ossi E, Bordin M C, Businaro M A, Marson P, Bonadonna P, Chiaramonte M, Boin F, Valenti M T, Fagiolo U
Institute of Internal Medicine, University of Padova, Italy.
Clin Exp Rheumatol. 1995 Nov-Dec;13 Suppl 13:S91-3.
Hepatitis C virus infection is closely associated not only with hepatic damage, but also with mixed cryoglobulinemia (MC) and other autoimmune and lymphoproliferative disorders. Because HCV is both hepatotropic and lymphotropic, the aim of this study was to investigate whether the genetic background may influence the clinical pattern seen in different patients.
Two groups of patients with HCV infection were studied: 16 with type II MC and 18 with chronic active hepatitis (CAH). 120 bone marrow donors were considered as the control group. In all patients HLA-A-B-C antigens were evaluated using the microlymphocytoxicity technique, and HLA-DR by the PCR-SSP method.
The frequency of the HLA antigens expressed was not precisely defined in the two groups. However, the HLA-B51 and B35 antigens, which are often correlated with autoimmune disorders, were highly expressed in the MC patients (31.2%) compared to the controls (6.9%) and to the CAH group (11%). Moreover, HLA-A9 with its split A24 were present in 50% of the MC patients. More interesting was the expression of the HLA-DR7 antigen, which was found only in the CAH group, suggesting that it may influence the specific liver involvement in HCV infections.
These findings indicate that the HLA system may play an important role in the clinical manifestations of HCV infection.
丙型肝炎病毒感染不仅与肝损伤密切相关，还与混合性冷球蛋白血症（MC）以及其他自身免疫性和淋巴增殖性疾病有关。由于HCV既嗜肝又嗜淋巴，本研究旨在调查遗传背景是否可能影响不同患者的临床模式。
对两组丙型肝炎病毒感染患者进行了研究：16例患有II型MC，18例患有慢性活动性肝炎（CAH）。120名骨髓供者被视为对照组。对所有患者使用微量淋巴细胞毒性技术评估HLA-A-B-C抗原，通过聚合酶链反应-序列特异性引物（PCR-SSP）方法评估HLA-DR。
两组中表达的HLA抗原频率未得到精确界定。然而，经常与自身免疫性疾病相关的HLA-B51和B35抗原在MC患者中高表达（31.2%），相比之下，对照组为（6.9%），CAH组为（11%）。此外，50%的MC患者存在与其分裂型A24相关的HLA-A9。更有趣的是HLA-DR7抗原的表达，仅在CAH组中发现，这表明它可能影响HCV感染中肝脏的特异性受累情况。
这些发现表明HLA系统可能在丙型肝炎病毒感染的临床表现中起重要作用。
