Mallick A, Bodenham A R
Academic Unit of Anaesthesia, General Infirmary at Leeds.
Br J Hosp Med. 1996;55(7):443-8.
Haemoglobin solutions have been developed as red cell substitutes from various sources, e.g. outdated human blood, and bovine and recombinant haemoglobins. Haemoglobins have been modified to reduce their high oxygen affinity, oncotic activity and to prolong their intravascular half-life. Aside from oxygen carriage, modified haemoglobin solutions have other interesting properties, including vasopressor effects and improvements in regional blood flow.
血红蛋白溶液已被开发为来自各种来源的红细胞替代物，例如过期的人血、牛血红蛋白和重组血红蛋白。血红蛋白已被修饰以降低其高氧亲和力、胶体渗透压活性并延长其血管内半衰期。除了携带氧气外，修饰后的血红蛋白溶液还有其他有趣的特性，包括血管加压作用和局部血流改善。
