de Luca B, Bures J
Dev Psychobiol. 1977 Jul;10(4):289-97. doi: 10.1002/dev.420100402.
The development of Leão's spreading depression (SD) of electroencephalographic activity was studied in young rats by recording the accompanying slow potential changes (SPC). The propagation rate of cortical SD increased from 1.65 mm/min on Day 15 to 2.6 mm/min on Day 20; the increase of SPC amplitude and the decrease of SPC duration were less evident over the same period. The SD elicited in the caudate nucleus by microinjections of KCl did not spread to neocortex in 20- and 30-day-old rats and transition occurred in only 5% of KCl applications in 40-day-old rats. Application of a pyrrolopyrimidine derivative (BW 57-271; 5 mg/kg) increased the cortico-caudate SD transition of 100% in rats aged 20 days or older and increased the SPC amplitude in both structures. The development of SD parameters can be ascribed to dendritic growth and to the decrease of extracellular space; the cortico-caudate propagation block can be ascribed to morphological immaturity of the transitional zone.
通过记录伴随的慢电位变化（SPC），研究了幼鼠中脑电图活动的莱奥扩散性抑制（SD）的发展。皮质SD的传播速度从第15天的1.65毫米/分钟增加到第20天的2.6毫米/分钟；同期SPC振幅的增加和SPC持续时间的减少不太明显。在20日龄和30日龄大鼠中，通过微量注射氯化钾在尾状核引发的SD未扩散至新皮质，而在40日龄大鼠中，仅5%的氯化钾注射出现了转变。应用一种吡咯并嘧啶衍生物（BW 57-271；5毫克/千克）可使20日龄及以上大鼠的皮质-尾状核SD转变率提高100%，并增加两个结构中的SPC振幅。SD参数的发展可归因于树突生长和细胞外空间的减少；皮质-尾状核传播阻滞可归因于过渡区的形态不成熟。
