Koroleva V I, Gorelova N A
Neirofiziologiia. 1983;15(3):226-34.
Properties of cortical spreading depression (SD) were studied at different phases of cyclic excitation occurring in the rat neocortex under low-frequency electrostimulation. SD waves appeared in the cortex spontaneously or were elicited by KCL microinjection. It is shown that the state preventing penetration of SD waves into the stimulated area (blockade of SD) developed during each cycle of excitation. The spatial extent of the SD blockade depended on the degree of excitation generalization over cerebral cortex. After the end of excitation the ability of the stimulated cortical area to conduct SD waves restored. In the intervals between the excitation cycles the SD waves duration was on the average half as long as before stimulation. The development of SD blockade during active phase and restoration of SD waves in the intervals confirms a hypothesis that K+-Na+ pump activation prevents the propagation of SD.
在低频电刺激下，对大鼠新皮质中周期性兴奋不同阶段的皮质扩散性抑制（SD）特性进行了研究。SD波在皮质中自发出现或通过微量注射氯化钾诱发。结果表明，在每个兴奋周期中，都会出现阻止SD波进入受刺激区域的状态（SD阻断）。SD阻断的空间范围取决于大脑皮质兴奋泛化的程度。兴奋结束后，受刺激皮质区域传导SD波的能力得以恢复。在兴奋周期之间的间隔期，SD波的持续时间平均只有刺激前的一半。活动期SD阻断的出现以及间隔期SD波的恢复证实了一个假设，即钾钠泵的激活会阻止SD的传播。
