Vinogradova L V, Koroleva V I, Bures J
Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow.
Brain Res. 1991 Jan 4;538(1):161-4. doi: 10.1016/0006-8993(91)90392-9.
About 40% of spreading depression (SD) waves elicited from the parieto-occipital cortex of anesthetised rats penetrated through the temporal lobe structures (amygdala) into the caudate nucleus. Almost 70% of these SD waves did not terminate in the caudate but returned to the cortex and spread through it toward the site of SD initiation. Longer cortico-caudate (5.9 +/- 0.1 min) than caudate-cortical (4.7 +/- 0.2 min) conduction times suggest that SD enters and leaves caudate through routes of different length. SD waves elicited by KCl microinjection into the caudate reached frontal and parieto-occipital cortical electrodes with latencies indicating that the transit point is 5 mm closer to the rostral than to the caudal electrode. The region best satisfying this condition corresponds to rostral claustrum. The directionally biased SD conduction through the transit zone provides a re-entry path for cortico-caudate-cortical SD propagation and forms thus a natural reverberator the small dimensions of which preclude generation of repetitive SD waves.
从麻醉大鼠顶枕叶皮质引发的约40%的扩散性抑制（SD）波穿过颞叶结构（杏仁核）进入尾状核。这些SD波中近70%并未在尾状核终止，而是返回皮质并通过皮质向SD起始部位扩散。皮质-尾状核传导时间（5.9±0.1分钟）长于尾状核-皮质传导时间（4.7±0.2分钟），这表明SD通过不同长度的路径进出尾状核。通过向尾状核微量注射氯化钾引发的SD波到达额叶和顶枕叶皮质电极，其潜伏期表明，过渡点距离头端电极比距离尾端电极近5毫米。最符合这一条件的区域对应于头端屏状核。通过过渡区的定向偏向性SD传导为皮质-尾状核-皮质SD传播提供了一条折返路径，从而形成了一个天然的回响器，其小尺寸阻止了重复性SD波的产生。
