感染人类免疫缺陷病毒的女性的宫颈上皮内瘤变
Cervical intra-epithelial neoplasia in women infected with human immunodeficiency virus.
作者信息
Bongain A, Rampal A, Durant J, Michiels J F, Dellamonica P, Gillet J Y
机构信息
Department of Obstetrics-Gynecology, Reproductive and Fetal Medicine, Hôpital St. Roch, Nice, France.
出版信息
Eur J Obstet Gynecol Reprod Biol. 1996 Apr;65(2):195-9. doi: 10.1016/0301-2115(95)02357-7.
OBJECTIVE
To investigate the relationship between human immunodeficiency virus (HIV) and cervical intra-epithelial neoplasia (CIN).
DESIGN
A prospective study to determine the prevalence of cervical intra-epithelial neoplasia in 111 HIV-positive women.
METHODS
In total, 111 HIV + women were enrolled and underwent cervical biopsy and CD4 T-lymphocyte determination. Of the 111 women, 26 (23.4%) had CIN and another 26 (23.4%) had histologic evidence of cervicitis.
RESULTS
No significant difference was found between transmission group, CDC stage of disease, CD4 T-lymphocyte count and pregnancy. There was a significant association with concomitant human papillomavirus (HPV) infection (P < 0.001).
CONCLUSION
Public health measures are needed to provide Papanicolaou smear screening and appropriate clinical follow-up and treatment of women infected with the human immunodeficiency virus.
目的
探讨人类免疫缺陷病毒（HIV）与宫颈上皮内瘤变（CIN）之间的关系。
设计
一项前瞻性研究，以确定111名HIV阳性女性中宫颈上皮内瘤变的患病率。
方法
总共招募了111名HIV阳性女性，她们接受了宫颈活检和CD4 T淋巴细胞测定。在这111名女性中，26名（23.4%）患有CIN，另外26名（23.4%）有宫颈炎的组织学证据。
结果
在传播组、疾病的美国疾病控制与预防中心（CDC）分期、CD4 T淋巴细胞计数和妊娠方面未发现显著差异。与同时感染人乳头瘤病毒（HPV）存在显著关联（P < 0.001）。
结论
需要采取公共卫生措施，为感染人类免疫缺陷病毒的女性提供巴氏涂片筛查以及适当的临床随访和治疗。
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