西沙必利诱导兔浦肯野纤维动作电位延长及早期后除极。
Cisapride-induced prolongation of cardiac action potential and early afterdepolarizations in rabbit Purkinje fibres.
作者信息
Puisieux F L, Adamantidis M M, Dumotier B M, Dupuis B A
机构信息
Laboratoire de Pharmacologie, Faculté de Médicine, Lille, France.
出版信息
Br J Pharmacol. 1996 Apr;117(7):1377-9. doi: 10.1111/j.1476-5381.1996.tb15295.x.
Abstract
Cisapride, a gastrointestinal prokinetic agent, has been associated with cases of Torsades de Pointes but its effects on the cardiac action potential have not been described. We investigated its electrophysiological effects on rabbit isolated Purkinje fibres. The results demonstrated that cisapride (0.01-10 microM) lengthened concentration-dependently the action potential duration without modifying other parameters and induced early after depolarizations and subsequent triggered activity. This typical class III antiarrhythmic effect, that showed "reverse" rate-dependence and was reduced by increasing external K concentration, can account for clinical arrhythmogenesis.
摘要
西沙必利是一种胃肠动力药，与多形性室性心动过速病例有关，但其对心脏动作电位的影响尚未见报道。我们研究了其对兔离体浦肯野纤维的电生理作用。结果表明，西沙必利（0.01 - 10微摩尔）浓度依赖性地延长动作电位时程，而不改变其他参数，并诱发早期后去极化及随后的触发活动。这种典型的III类抗心律失常作用表现出“反向”频率依赖性，且随着细胞外钾浓度升高而减弱，这可以解释其临床心律失常的发生机制。
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