Masada T, Itano T, Fujisawa M, Miyamoto O, Tokuda M, Matsui H, Nagao S, Hatase O
Department of Neurological Surgery, Kagawa Medical School, Japan.
Neuroreport. 1996 Jan 31;7(2):446-8. doi: 10.1097/00001756-199601310-00017.
The left vagus nerve was stimulated during transient forebrain ischaemia in gerbils. The animals were exposed to 3 min of forebrain ischaemic insult at 37.5 degrees C. On day 5 post-ischaemia, the animals were perfusion-fixed for qualitative and quantitative histopathological analyses. High current stimulation of the vagus nerve inhibited ischaemic neuronal damage in the hippocampal CA1 sector (p < 0.01), but low current stimulation did not (p < 0.01). These effects might have been due to inhibition of the effects of excitatory amino acids during ischaemia. These results indicate that vagus nerve stimulation might be protective to neurones subjected to ischaemic insult.
在沙鼠短暂性前脑缺血期间刺激其左侧迷走神经。动物在37.5摄氏度下接受3分钟的前脑缺血损伤。缺血后第5天，将动物灌注固定以进行定性和定量组织病理学分析。迷走神经的高电流刺激可抑制海马CA1区的缺血性神经元损伤（p<0.01），但低电流刺激则不能（p<0.01）。这些作用可能是由于在缺血期间抑制了兴奋性氨基酸的作用。这些结果表明，迷走神经刺激可能对遭受缺血损伤的神经元具有保护作用。
