Gavrias V, Andrianopoulos A, Gimeno C J, Timberlake W E
Myco Pharmaceuticals Inc., Cambridge, Massachusetts 02139, USA.
Mol Microbiol. 1996 Mar;19(6):1255-63. doi: 10.1111/j.1365-2958.1996.tb02470.x.
Diverse eukaryotic organisms share developmental transcription factors with homologous DNA-binding domains. We showed that the developmental regulator AbaA, a member of the ATTS/TEA (AbaA, TEF-1, TEC1, Scalloped/TEF-1, TEC1, AbaA) class of transcription factors of the filamentous fungus Aspergillus nidulans, induces pseudohyphal development in the yeast Saccharomyces cerevisiae. The S. cerevisiae homologue of AbaA, TEC1p, is required for this morphological transition. We provide evidence that TEC1p functions in co-operation with STE12p to induce pseudohyphal development.
多种真核生物共享具有同源DNA结合结构域的发育转录因子。我们发现，丝状真菌构巢曲霉的ATTS/TEA（AbaA、TEF-1、TEC1、扇贝状/TEF-1、TEC1、AbaA）类转录因子成员、发育调节因子AbaA可诱导酿酒酵母中的假菌丝发育。AbaA在酿酒酵母中的同源物TEC1p是这种形态转变所必需的。我们提供的证据表明，TEC1p与STE12p协同作用以诱导假菌丝发育。
