可卡因依赖患者的异常视网膜电图。与渴望的关系。
Abnormal electroretinogram in cocaine-dependent patients. Relationship to craving.
作者信息
Roy M, Smelson D A, Roy A
机构信息
Department of Ophthalmology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark 07103, USA.
出版信息
Br J Psychiatry. 1996 Apr;168(4):507-11. doi: 10.1192/bjp.168.4.507.
BACKGROUND
The retina contains high concentrations of dopamine. We previously reported that recently withdrawn cocaine-dependent patients had significantly reduced blue cone b wave amplitude responses on the electroretinogram (ERG). In this study we wished to examine if there was a relationship between cocaine craving and reduced blue cone b wave ERG responses.
METHODS
A series of 14 recently withdrawn cocaine-dependent patients completed a 45-item cocaine craving questionnaire shortly before the ERG.
RESULTS
Cocaine dependent patients who had a reduced ( < 0.5 microvolts) blue cone b wave ERG response had significantly higher cocaine craving scores than patients without a reduced blue cone ERG response. There was also a significant negative correlation between blue cone b wave amplitude responses and scores on the cocaine craving questionnaire.
CONCLUSIONS
A reduced blue cone b wave ERG response may identify recently withdrawn cocaine-dependent patients with biological dysregulation and increased cocaine craving.
背景
视网膜含有高浓度的多巴胺。我们之前报道过，近期戒毒的可卡因依赖患者在视网膜电图（ERG）上的蓝锥细胞b波振幅反应显著降低。在本研究中，我们希望检验可卡因渴望与蓝锥细胞b波ERG反应降低之间是否存在关联。
方法
14名近期戒毒的可卡因依赖患者在进行ERG检查前不久完成了一份45项的可卡因渴望调查问卷。
结果
蓝锥细胞b波ERG反应降低（<0.5微伏）的可卡因依赖患者的可卡因渴望得分显著高于蓝锥细胞ERG反应未降低的患者。蓝锥细胞b波振幅反应与可卡因渴望调查问卷得分之间也存在显著的负相关。
结论
蓝锥细胞b波ERG反应降低可能表明近期戒毒的可卡因依赖患者存在生物调节异常且可卡因渴望增加。
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