Hill L M, Lazebnik N, Many A
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pennsylvania, USA.
J Ultrasound Med. 1996 May;15(5):395-9. doi: 10.7863/jum.1996.15.5.395.
To determine the effect of indomethacin on the amniotic fluid index of individual fetuses in multiple gestations, we evaluated seven sets of twins and two sets of triplets in preterm labor (eight cases) or with polyhydramnios (one case). The dose of oral indomethacin was either 25 mg every 12 hours or 25 mg every 6 hours. The amniotic fluid volume of individual amniotic sacs was estimated serially by the amniotic fluid index. When an oral dose of indomethacin of 25 mg every 6 hours was used, oligohydramnios eventually occurred in five of eight amniotic sacs and a subjective decrease in amniotic fluid occurred in one sac. Oligohydramnios was detected in only one of 13 amniotic sacs when the dose of indomethacin was 25 mg every 12 hours. The amniotic fluid volume returned to normal in these seven amniotic sacs within 4 days of discontinuing indomethacin. We conclude that maternal indomethacin therapy has a variable effect on the individual amniotic fluid volumes in multiple gestations.
为了确定吲哚美辛对多胎妊娠中单个胎儿羊水指数的影响，我们评估了7对双胞胎和2组三胞胎，这些孕妇处于早产（8例）或羊水过多（1例）状态。口服吲哚美辛的剂量为每12小时25毫克或每6小时25毫克。通过羊水指数连续估计单个羊膜囊的羊水量。当使用每6小时25毫克的口服吲哚美辛剂量时，8个羊膜囊中最终有5个出现羊水过少，1个羊膜囊出现主观羊水减少。当吲哚美辛剂量为每12小时25毫克时，13个羊膜囊中仅1个检测到羊水过少。在停用吲哚美辛后的4天内，这7个羊膜囊的羊水量恢复正常。我们得出结论，母亲使用吲哚美辛治疗对多胎妊娠中单个羊水量有不同的影响。
