Ehlers C L, Phillips E, Parry B L
Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, USA.
Biol Psychiatry. 1996 Apr 15;39(8):720-32. doi: 10.1016/0006-3223(95)00183-2.
This study evaluated electrophysiological (EEG, ERGs), and cognitive (neuropsychological testing) responses in patients with late luteal phase dysphoric disorder (LLPDD, DSM-III-R) and controls over the menstrual cycle. In both groups, the frequency and stability of electroencephalogram (EEG) alpha activity significantly differed over the menstrual cycle. The latency of the P3 components of the auditory event-related potentials (ERPs) did not vary as a function of the menstrual cycle, but the P3 latency was found to be later in LLPDD subjects as a group. When the LLPDD subjects were assessed based on family history of alcoholism, it was found that those with alcoholic relatives had more high-frequency alpha (9-12 Hz) in their EEG, lower P3 component amplitudes, and longer P3 component latencies when compared to LLPDD subjects without alcoholic relatives or controls. These data suggest that LLPDD may have persistent neurophysiological correlates, some of which are also in common with risk for alcoholism.
本研究评估了晚黄体期烦躁障碍（LLPDD，DSM-III-R）患者及对照组在月经周期中的电生理反应（脑电图、视网膜电图）和认知反应（神经心理学测试）。在两组中，脑电图（EEG）α活动的频率和稳定性在月经周期中存在显著差异。听觉事件相关电位（ERP）的P3成分潜伏期并不随月经周期而变化，但作为一个群体，LLPDD受试者的P3潜伏期较晚。当根据酗酒家族史对LLPDD受试者进行评估时，发现与无酗酒亲属的LLPDD受试者或对照组相比，有酗酒亲属的受试者脑电图中有更多的高频α波（9-12Hz），P3成分波幅更低，P3成分潜伏期更长。这些数据表明，LLPDD可能存在持续的神经生理学关联，其中一些也与酗酒风险有关。
