de Bravo M G, Tournier H, Schinella G, Viaggi M, Quintans C
Instituto de Investigaciones Bioquímicas, Universidad Nacional de La Plata, Argentina.
Medicina (B Aires). 1995;55(6):670-4.
We have studied the effect of a gamma-linolenic acid (18:3 n-6, GLA)-supplemented diet on the growth of a human lung mucoepidermoid carcinoma (HLMC) implanted in athymic mice and on its uptake of human low density lipoproteins labeled with 99mTc (99mTc-LDL). Mice bearing the HLMC were divided into two experimental groups. One of them was administered a control diet (C diet) and the other one was given a diet supplemented with 25 mg GLA/g pellet (GLA diet) for three weeks (Table 1). A tumor growth inhibition with the GLA diet was evident at the second week of treatment, and a marked inhibition (56%) was reached at the end of the third week (Fig. 1). The GLA diet produced some changes in the total fatty acid composition of tumor, plasma and liver of host mice: GLA and arachidonic acid (20:4 n-6, AA) induced significant increases, whereas oleic (18:1 n-9, OA) and linoleic acids (18:2 n-6, LA) were decreased (Table 2). Tumors of those animals fed both diets were labeled by 99mTc-LDL, and no difference was observed in the ratio of tumor/liver and tumor/kidney uptake of host animal (Table 3). Results obtained using this experimental model suggest that the inhibitory effect of GLA on tumor growth is not related to the LDL tumor uptake.
我们研究了补充γ-亚麻酸（18:3 n-6，GLA）的饮食对植入无胸腺小鼠体内的人肺黏液表皮样癌（HLMC）生长及其摄取用99mTc标记的人低密度脂蛋白（99mTc-LDL）的影响。携带HLMC的小鼠被分为两个实验组。其中一组给予对照饮食（C饮食），另一组给予补充了25 mg GLA/克颗粒的饮食（GLA饮食），持续三周（表1）。在治疗的第二周，GLA饮食对肿瘤生长的抑制作用明显，在第三周结束时达到显著抑制（56%）（图1）。GLA饮食使宿主小鼠肿瘤、血浆和肝脏的总脂肪酸组成发生了一些变化：GLA和花生四烯酸（20:4 n-6，AA）显著增加，而油酸（18:1 n-9，OA）和亚油酸（18:2 n-6，LA）减少（表2）。两种饮食喂养的动物的肿瘤均被99mTc-LDL标记，宿主动物的肿瘤/肝脏和肿瘤/肾脏摄取率没有差异（表3）。使用该实验模型获得的结果表明，GLA对肿瘤生长的抑制作用与LDL肿瘤摄取无关。
