Ibbotson S H, Speight E L, Macleod R I, Smart E R, Lawrence C M
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
Br J Dermatol. 1996 Mar;134(3):420-3.
In this study we examined the prevalence of mercury hypersensitivity in patients with oral lichenoid reactions (OLR) and the effect of amalgam replacement in subjects with amalgams adjacent to OLR irrespective of their mercury sensitivity status. One hundred and ninety-seven patients with oral problems were examined: 109 with OLR, 22 with oral and generalized lichen planus, and 66 with other oral diagnoses, including aphthous ulcers and orofacial granulomatosis. Nineteen per cent of patients with OLR reacted to mercury on patch testing, significantly more than in those with generalized lichen planus (0%) and in those with other oral diagnoses (3%). Twenty-two patients with OLR and adjacent amalgams had amalgam replacement and, in 16 of 17 mercury-positive subjects and three of four mercury-negative subjects, the OLR resolved after amalgam removal. In conclusion, we found a significantly increased prevalence of mercury hypersensitivity in patients with localized OLR in comparison to subjects with other oral problems. Amalgam replacement resulted in resolution of OLR in the majority of patients with amalgams adjacent to OLR irrespective of their mercury sensitivity status.
在本研究中，我们调查了口腔苔藓样反应（OLR）患者中汞超敏反应的患病率，以及不论汞敏感状态如何，对OLR附近有汞合金的受试者进行汞合金置换的效果。对197例口腔问题患者进行了检查：109例患有OLR，22例患有口腔及全身性扁平苔藓，66例患有其他口腔疾病，包括复发性阿弗他溃疡和口面部肉芽肿病。19%的OLR患者在斑贴试验中对汞有反应，显著高于全身性扁平苔藓患者（0%）和其他口腔疾病患者（3%）。22例患有OLR且附近有汞合金的患者进行了汞合金置换，在17例汞阳性受试者中的16例以及4例汞阴性受试者中的3例中，OLR在汞合金去除后得到缓解。总之，我们发现与其他口腔问题患者相比，局限性OLR患者中汞超敏反应的患病率显著增加。不论汞敏感状态如何，对OLR附近有汞合金的大多数患者进行汞合金置换可使OLR得到缓解。
