Ghaleyani Parichehr, Sardari Farimah, Akbari Mojtaba
Department of Oral Medicine and Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2012;1:73. doi: 10.4103/2277-9175.102977. Epub 2012 Oct 31.
The objective of this study was to assess the level of salivary IgA and IgG in oral lichen planus (OLP) and oral lichenoid reactions (OLR) patients as diagnostic factors to the differential diagnosis of OLP, OLR diseases.
Saliva sample were obtained from 50 OLP, 50 OLR patients and 50 healthy subjects between April 2010 and October 2011. The clinical relevant data taken into account were: Demographical data, previous medication, and level of salivary IgA and IgG. Each sample was assessed to determine the level of salivary IgA by ELISA test and salivary IgG by radial immune diffusion.
The mean of salivary IgA and IgG in patients were 119.01 ± 114.18 mic/ml and 3.25 ± 1.81 mic/ml, respectively. There were no significant differences for salivary IgA and IgG between OLP and OLR, but the mean of salivary IgA and IgG in OLP and OLR patients were significantly more than normal group (P-value < 0.05). The cut-off value was set at >72 mic/ml for salivary IgA in both OLP and OLR groups and set at >3.7 mic/ml for salivary IgG. On comparing the AUCs, there was no significant difference between AUCs for IgA (0.715 ± 0.05vs. 0.69 ± 0.5, for OLP and OLR patients, respectively,P-value = 0.7) and IgG (0.681 ± 0.05 vs. 0.548 ± 0.06, for OLP and OLR patients, respectively, P-value = 0.1).
Our results showed that the level of salivary IgA and IgG in OLP and OLR patients is higher than healthy controls, but they cannot be used as diagnostic factors to the differential diagnosis of OLP and OLR.
本研究的目的是评估口腔扁平苔藓（OLP）和口腔苔藓样反应（OLR）患者唾液中IgA和IgG水平，作为OLP、OLR疾病鉴别诊断的诊断因素。
2010年4月至2011年10月期间，从50例OLP患者、50例OLR患者和50名健康受试者中采集唾液样本。考虑的临床相关数据包括：人口统计学数据、既往用药情况以及唾液中IgA和IgG水平。通过酶联免疫吸附测定（ELISA）试验评估每个样本的唾液IgA水平，通过放射免疫扩散法评估唾液IgG水平。
患者唾液中IgA和IgG的平均值分别为119.01±114.18微克/毫升和3.25±1.81微克/毫升。OLP和OLR患者之间唾液IgA和IgG无显著差异，但OLP和OLR患者唾液中IgA和IgG的平均值显著高于正常组（P值<0.05）。OLP组和OLR组唾液IgA的临界值均设定为>72微克/毫升，唾液IgG的临界值设定为>3.7微克/毫升。比较曲线下面积（AUC）时，IgA的AUC在OLP和OLR患者之间无显著差异（分别为0.715±0.05和0.69±0.5，P值=0.7），IgG的AUC也无显著差异（分别为0.681±0.05和0.548±0.06，P值=0.1）。
我们的结果表明，OLP和OLR患者唾液中IgA和IgG水平高于健康对照组，但它们不能作为OLP和OLR鉴别诊断的诊断因素。
