De Berker D, Windebank K, Sviland L, Kingma D W, Carter R, Rees J L
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
Br J Dermatol. 1996 Mar;134(3):554-8.
An 8-year-old boy presented with a 10-week history of ulcerating lesions which were histologically and immunocytochemically consistent with the diagnosis of angiocentric T-cell lymphoma. The disease was limited to the skin and resolved with no chemotherapy. Angiocentric T-cell lymphoma is commonly a disease with considerable morbidity and is often fatal. Epstein-Barr virus (EBV) could not be identified in involved tissue by immunostaining or by in situ hybridization. We consider whether the uncharacteristic absence of EBV in this case has prognostic significance.
一名8岁男孩出现溃疡性病变，病史长达10周，组织学和免疫细胞化学检查结果与血管中心性T细胞淋巴瘤的诊断相符。该病仅限于皮肤，未进行化疗即痊愈。血管中心性T细胞淋巴瘤通常是一种发病率相当高且往往致命的疾病。通过免疫染色或原位杂交，在受累组织中未发现爱泼斯坦-巴尔病毒（EBV）。我们思考了该病例中EBV的异常缺失是否具有预后意义。
