Li L, Yu H, Pan J
Nephrology Institute, Beijing Medical University.
Zhonghua Nei Ke Za Zhi. 1995 Oct;34(10):670-2.
It was found in our previous studies that two Chinese herbs Astragali and Angelica (A&A) together with high protein diet could ameliorate the lowering of serum albumin level and increase the synthesis rate of protein as shown by 15N-glicine tracer priming protein turnover study in nephrotic rats. Further experiment was designed to investigate the role of A&A and high protein intake in protein dynamic study and nitrogen balance in nephrotic patients. The level of serum total protein (STP), serum albumin (SA), urinary protein loss (UP), serum cholesterol (Cho) and index number of protein turnover and nitrogen balance in 7 patients were measured before and after treatment of 30 days with A&A. The results showed that after treatment the patients had significantly increased STA and SA (44.3 +/- 5.60 vs 49.7 +/- 6.80 P < 0.01; 22.6 +/- 0.42 vs. 29.4 +/- 7.40 P < 0.05), decreased UP and Cho (6.54 +/- 1.83 vs 4.63 +/- 1.33 P < 0.05; 9.69 +/- 2.31 vs. 7.82 +/- 1.95 P < 0.05) and increased net rates of total protein synthesis (1.06 +/- 0.03 vs 1.27 +/- 0.12 P < 0.05). It is concluded that A&A together with high protein intake could improve the disorder of protein metabolism and increase the level of serum protein by improving the net rate of protein synthesis in nephrotic patients.
我们之前的研究发现，两种中药黄芪和当归（A&A）与高蛋白饮食一起，可改善肾病大鼠血清白蛋白水平的降低，并增加蛋白质合成率，如通过15N-甘氨酸示踪启动蛋白周转研究所示。进一步的实验旨在研究A&A和高蛋白摄入在肾病患者蛋白质动力学研究和氮平衡中的作用。在7例患者接受A&A治疗30天前后，测量其血清总蛋白（STP）、血清白蛋白（SA）、尿蛋白丢失（UP）、血清胆固醇（Cho）水平以及蛋白质周转指数和氮平衡。结果显示，治疗后患者的STA和SA显著增加（44.3±5.60对49.7±6.80，P<0.01；22.6±0.42对29.4±7.40，P<0.05），UP和Cho降低（6.54±1.83对4.63±1.33，P<0.05；9.69±2.31对7.82±1.95，P<0.05），总蛋白合成净率增加（1.06±0.03对1.27±0.12，P<0.05）。结论是，A&A与高蛋白摄入一起可改善肾病患者的蛋白质代谢紊乱，并通过提高蛋白质合成净率来增加血清蛋白水平。
