Shangguan C, Wang W, Sun J
Second Affliated Hospital, Xian Medical University.
Zhonghua Nei Ke Za Zhi. 1995 Nov;34(11):761-3.
Three hundred and sixteen patients diagnosed as skeletal fluorosis roentgenologically and having no other diseases were divided randomly into 2 groups, matchable in sex distribution, age, functional state and X-ray findings. In the treated group every patient took 200mg vitamin C twice a day, while in the control group placebo tablets. The duration of treatment was 3 months. The therapeutic effect was evaluated by measuring the joint angle and power of gripping and studying the X-ray film and electromyogram. 38 kinds of biochemical parameters were measured simultaneously with a MCA-3 autobiochemical analyser. The results were as follows, (1) The total effective rate in the treated group was 12.84%, chi 2 = 0.556, P > 0.05, so there is no obvious effect in treating skeletal fluorosis with vitamin C. (2) The electromyogram in the treated group showed a recovering rate of 20.00%, chi 2 = 5.9, P > 0.01. It is further shown that there is no effect in treating skeletal fluorosis with vitamin C. (3) 38 kinds of biochemical parameters measured simultaneously and the X-ray findings also showed that vitamin C is not effective. Thus the validity of using vitamin C as the drug of first choice to treat skeletal fluorosis is to be queried.
316例经X线诊断为氟骨症且无其他疾病的患者被随机分为2组，两组在性别分布、年龄、功能状态及X线表现方面具有可比性。治疗组患者每日2次，每次服用200mg维生素C，而对照组服用安慰剂片。治疗持续3个月。通过测量关节角度和握力、研究X线片和肌电图来评估治疗效果。同时使用MCA - 3自动生化分析仪测量38种生化参数。结果如下：(1)治疗组总有效率为12.84%，χ2 = 0.556，P>0.05，因此维生素C治疗氟骨症无明显效果。(2)治疗组肌电图显示恢复率为20.00%，χ2 = 5.9，P>0.01。进一步表明维生素C治疗氟骨症无效。(3)同时测量的38种生化参数及X线表现也显示维生素C无效。因此，将维生素C作为治疗氟骨症的首选药物的有效性值得质疑。
