Shang Y D, Liu X M, Cai Z, Yang M S
Department of Neurology, Tongji Hospital, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1995;15(2):68-72. doi: 10.1007/BF02887904.
In the present study, the plasma fibrinolytic activity in 30 cases of cortical artery territory cerebral infarction (CACI) and 32 cases of perforating artery territory cerebral infarction (PACI) within 3 days after ictus, and 30 sex- and age-matched controls without cardio-cerebrovascular diseases were evaluated by a comprehensive panel of assay, including the plasma tPA activity, PAI activity, endothelial capacity of tPA release and PAI/tPA ratio. The results showed that the plasma fibrinolysis and the endothelial potential to release tPA responding to stimulation in both subtypes of the patients were significantly lower than those in the controls, which provide the theoretical basis for carrying out the thrombolytic therapy in the ischemic stroke. And the study also suggested that increased plasma PAI activity could increase the risk of AS thrombotic events with increased serum triglyceride level.
在本研究中，对30例皮质动脉区脑梗死（CACI）患者和32例穿支动脉区脑梗死（PACI）患者发病后3天内的血浆纤溶活性进行评估，并与30例无心脑血管疾病、年龄和性别匹配的对照者进行比较，评估项目包括血浆组织型纤溶酶原激活物（tPA）活性、纤溶酶原激活物抑制剂（PAI）活性、tPA释放的内皮能力以及PAI/tPA比值。结果显示，两类患者的血浆纤溶作用以及刺激后内皮释放tPA的能力均显著低于对照组，这为缺血性卒中的溶栓治疗提供了理论依据。该研究还表明，血浆PAI活性增加会随着血清甘油三酯水平升高而增加动脉粥样硬化血栓形成事件的风险。
