Zhang S, Sun B, Zhang J, Li F, Lei S, Cheng D, Yang X, Tan Y, Yao X, Li T
Department of Pathology, First Affiliated Hospital.
Hua Xi Yi Ke Da Xue Xue Bao. 1995 Dec;26(4):378-80.
The effects of Tetrandrine (Tet) on intraacinous pulmonary arteries (IAPA) and bemodynamics were studied by means of a rat pulmonary hypertension model induced by monocrotaline. The results showed that Tet could reduce the contractive pressure of pulmonary artery, right ventricle and right atrium of heart by 28.0%, 28.3%, and 31.5% respectively. It could also decrease the vascular degeneration of endoepithelial cells of IAPA, the endoepithelial subcavity, the collagens of medial membrane and the numbers of smooth muscles of IAPA.
通过用野百合碱诱导大鼠肺动脉高压模型，研究汉防己甲素（Tet）对腺泡内肺动脉（IAPA）及血液动力学的影响。结果显示，Tet可使肺动脉、右心室及右心房的收缩压分别降低28.0%、28.3%和31.5%。它还可减轻IAPA内皮细胞、内皮细胞下腔的血管退变，减少IAPA中膜的胶原蛋白及平滑肌数量。
