Zhang Y, Yaegashi H, Takahashi T
Department of Pathology, First Teaching Hospital, Normal Bethune University of Medical Sciences, Changchun.
Zhonghua Bing Li Xue Za Zhi. 1995 Dec;24(6):363-5.
The 3 dimensional reconstruction electrocomputor was used to study the distribution of atypia epithelia in 50 cases of large intestinal adenoma which were taken by fibercoloscopic resection. The 0.2 mm interval serial sections were stained with HE. Carcinomatous changes in adenomas were found in 17 cases, the rate being 34%. The average size of intraadenoma carcinoma being 3.4 times that of adenoma. The larger the adenoma, the higher the cancer rate. But the adenoma to cancer rate is high (25%) in Ips type adenoma of small size with pedicle. The size of adenoma is not associated with allotype incidence. 14 of the 17 cases were detected by study of conventional paraffin block slides, missed diagnosis rate being 18%. The serial sections must be made with intervals less than 0.6 mm in order to prevent missed diagnosis. This method is also of significance to determine if the excision site is cancer free.
应用三维重建电子计算机研究经纤维结肠镜切除的50例大肠腺瘤中异型上皮的分布情况。间隔0.2mm连续切片作HE染色。发现17例腺瘤有癌变，癌变率为34%。腺瘤内癌的平均大小为腺瘤的3.4倍。腺瘤越大，癌变率越高。但带蒂小尺寸的Ips型腺瘤癌变率也高（25%）。腺瘤大小与异型发生率无关。17例中的14例通过传统石蜡块切片检查发现，漏诊率为18%。为防止漏诊，连续切片间隔必须小于0.6mm。该方法对于确定切除部位是否无癌也具有重要意义。
