Zhang D, Zhang R, Zhang D
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.
Zhonghua Zhong Liu Za Zhi. 1996 Jan;18(1):48-50.
Forty patients with pleural mesothelioma confirmed pathologically including 2 benign and 38 malignant lesions are reported. In the 38 malignant mesotheliomas, 12 were histopathologically defined while the rest were unclassified. In this series, 33 surgical resections and 3 thoracotomy biopsies were carried out, whereas 4 patients were not operated. In 36 thoracotomies, there was one death with an operative mortality of 2.8% (1/36). Of 33 surgical resections, 10 (31%) received combined therapy. Of the 3 thoracotomy biopsy cases, postoperative irradiation was given to one, irradiation plus chemotherapy to the second and no treatment to the third. In 4 who were not operated, one died without treatment, two accepted chemotherapy and the fourth was treated with irradiation plus chemotherapy. Only two (5%) of these 40 patients had history of exposure to asbestos. The pre- and intra-operative diagnostic conformity rate was 50%. Ten patients were lost from follow-up. The longest survival was twelve years and one month. The authors sum-up their 31-year (1963-1994) experience of this disease and discuss the occupational factors in etiology, clinical diagnosis, treatment options and the significance of pathological types on prognosis of pleural mesothelioma.
报告了40例经病理确诊的胸膜间皮瘤患者，其中包括2例良性病变和38例恶性病变。在38例恶性间皮瘤中，12例经组织病理学明确诊断，其余未分类。在本系列研究中，进行了33例手术切除和3例开胸活检，4例患者未接受手术。在36例开胸手术中，有1例死亡，手术死亡率为2.8%（1/36）。在33例手术切除病例中，10例（31%）接受了联合治疗。在3例开胸活检病例中，1例术后接受了放疗，第2例接受了放疗加化疗，第3例未接受治疗。在4例未接受手术的患者中，1例未治疗死亡，2例接受了化疗，第4例接受了放疗加化疗。这40例患者中只有2例（5%）有石棉接触史。术前和术中诊断符合率为50%。10例患者失访。最长生存期为12年零1个月。作者总结了他们31年（1963 - 1994年）对这种疾病的经验，并讨论了病因学中的职业因素、临床诊断、治疗选择以及病理类型对胸膜间皮瘤预后的意义。
