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[血瘀型偏头痛患者血小板超微结构的研究]

[Study on ultrastructure of platelets in migraine patients with blood stasis type].

作者信息

Wang D N, Chen B T, Zhou Y L

机构信息

252 Hospital of PLA, Hebei.

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Dec;15(12):716-8.

PMID:8732137
Abstract

To study the relationship between ultrastructure of platelets and migraine patients with blood stasis type (MBS). The morphologic appearance and aggregation of platelets in MBS patients were examined before and after treatment with Tongbike oral liquor (20 cases in treated group and.10 in control). The results showed that the MBS patients' platelets appeared irregular, easy to aggregate and adhere to red cells, which was more severe when ADP was added, but improved after treated with Chinese medicinal herbs. According to the results it was assumed that platelets from MBS patients were in an abnormal activated state, the abnormal morphology and functional disturbance might be the pathologic basis of MBS. Tongbike oral liquor could markedly improve the morphologic and functional state of platelets, which was relevant to the inhibition of platelet aggregation and the inducing of platelet depolymerization.

摘要

研究血瘀型偏头痛患者血小板超微结构的关系。观察通痹克口服液治疗前后血瘀型偏头痛患者(治疗组20例,对照组10例)血小板的形态及聚集情况。结果显示,血瘀型偏头痛患者血小板形态不规则,易聚集并黏附于红细胞,加入二磷酸腺苷(ADP)后更为明显,但经中药治疗后有所改善。根据结果推测,血瘀型偏头痛患者血小板处于异常激活状态,其形态异常及功能紊乱可能是血瘀型偏头痛的病理基础。通痹克口服液能显著改善血小板的形态及功能状态,这与抑制血小板聚集和诱导血小板解聚有关。

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