Souêtre E, Martin P, Lozet H, Monteban H
Int Clin Psychopharmacol. 1996 Mar;11(1):45-52. doi: 10.1097/00004850-199603000-00006.
Quality of life is one of the effectiveness measures used to assess the impact of medical interventions. This paper describes results of a study on quality of life of depressed patients treated with fluoxetine or tricyclic antidepressants (TCAs) such as amitriptyline and clomipramine. The quality of life of patients was measured using the Short Form (SF-36), a widely accepted and validated questionnaire. Depressed patients (n = 845) were observed using a cross-sectional design. Patients who had been under treatment for at least 1 week (amitriptyline, clomipramine or fluoxetine) and met the DSM-III-R criteria for major depressive disorder were included. Similar sociodemographic profiles were found across treatment groups. However, more patients with a history of depression were found in the TCA vs the fluoxetine group. Compliance was dramatically lower and length of treatment higher for TCA-treated groups. Controlling for confounding variables, the TCA-treated group also scored lower than the fluoxetine-treated one for general health perception, and social and physical functioning. These differences are not explained by symptom severity since Hamilton scores were similar across treatment groups. These results suggest that fluoxetine treatment may be associated with higher levels of social functioning and health perception than usual TCA treatment.
生活质量是用于评估医学干预措施影响的有效性指标之一。本文描述了一项关于使用氟西汀或三环类抗抑郁药（如阿米替林和氯米帕明）治疗的抑郁症患者生活质量的研究结果。使用简表36健康调查（SF - 36）对患者的生活质量进行测量，这是一种被广泛接受并经过验证的问卷。采用横断面设计观察了845名抑郁症患者。纳入了接受治疗至少1周（服用阿米替林、氯米帕明或氟西汀）且符合《精神疾病诊断与统计手册》第三版修订本（DSM - III - R）中重度抑郁症标准的患者。各治疗组的社会人口学特征相似。然而，与氟西汀组相比，三环类抗抑郁药组中有更多有抑郁症病史的患者。三环类抗抑郁药治疗组的依从性显著更低，治疗时间更长。在控制混杂变量后，三环类抗抑郁药治疗组在总体健康感知、社会和身体功能方面的得分也低于氟西汀治疗组。由于各治疗组的汉密尔顿评分相似，这些差异不能用症状严重程度来解释。这些结果表明，与常规三环类抗抑郁药治疗相比，氟西汀治疗可能与更高水平的社会功能和健康感知相关。
