Warner J P, Gledhill J A, Wakeling A
University Department of Psychiatry, Royal Free Hospital, London, UK.
Int Clin Psychopharmacol. 1996 Mar;11(1):65-6. doi: 10.1097/00004850-199603000-00011.
The role of risperidone in the management of treatment-resistant schizophrenia remains unclear. We describe two patients with treatment-resistant schizophrenia characterized by unremitting delusions, thought disorder and self-neglect who had a sustained improvement in their symptoms soon after starting risperidone. Risperidone may be a suitable alternative to clozapine in some patients unresponsive to conventional antipsychotics.
利培酮在难治性精神分裂症治疗中的作用仍不明确。我们描述了两名难治性精神分裂症患者，其特征为持续存在妄想、思维障碍和自我忽视，在开始使用利培酮后症状很快持续改善。对于一些对传统抗精神病药物无反应的患者，利培酮可能是氯氮平的合适替代药物。
