Heller D S, Gordon R E, Westhoff C, Gerber S
College of Physicians and Surgeons, Columbia University, New York 10032, USA.
Am J Ind Med. 1996 May;29(5):435-9. doi: 10.1002/(SICI)1097-0274(199605)29:5<435::AID-AJIM1>3.0.CO;2-L.
Epidemiologic studies suggest increased risk of epithelial ovarian cancer in female asbestos workers and increased risk of malignancy in general in household contacts of asbestos workers. Ovaries were studied from 13 women with household contact with men with documented asbestos exposure and from 17 women undergoing incidental oophorectomy. Ovarian tissue was examined by analytic electron microscopy. Significant asbestos fiber burdens were detected in 9 out of 13 women with household asbestos exposure (69.2%), and in 6 out of 17 women who gave no exposure history (35%). Three exposed women had asbestos counts over 1 million fibers per gram wet weight (23%), but only 1/17 women without an exposure history had a count that high (6%). Although asbestos has been documented as a contaminant of some older cosmetic talc preparations, the chrysotile and crocidolite types of asbestos we detected are more indicative of background and/or occupational exposure. This study demonstrates that asbestos can reach the ovary. Although the number of subjects is small, asbestos appears to be present in ovarian tissue more frequently and in higher amounts in women with a documentable exposure history.
流行病学研究表明，女性石棉工人患上皮性卵巢癌的风险增加，石棉工人的家庭接触者患恶性肿瘤的总体风险增加。对13名与有石棉接触记录的男性有家庭接触的女性以及17名接受偶然卵巢切除术的女性的卵巢进行了研究。通过分析电子显微镜检查卵巢组织。在13名有家庭石棉接触的女性中，有9名（69.2%）检测到大量石棉纤维负荷，在17名无接触史的女性中，有6名（35%）检测到大量石棉纤维负荷。3名接触石棉的女性每克湿重的石棉纤维计数超过100万根（23%），但在17名无接触史的女性中，只有1名（6%）的计数达到如此之高。尽管石棉已被证明是一些较旧的化妆品滑石粉制剂的污染物，但我们检测到的温石棉和青石棉类型更能表明是背景和/或职业接触。这项研究表明石棉可以到达卵巢。尽管研究对象数量较少，但在有可记录接触史的女性中，石棉似乎更频繁且以更高的量存在于卵巢组织中。
