Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia.
J Womens Health (Larchmt). 2020 Jan;29(1):111-118. doi: 10.1089/jwh.2019.7752. Epub 2019 Jul 16.
Asbestos is an established cause of several cancers, including mesothelioma and ovarian cancer. Incidence of mesothelioma, the sentinel asbestos-associated cancer, varies by state, likely reflecting different levels of asbestos exposure. We hypothesized that states with high mesothelioma incidence may also have high ovarian cancer incidence. Using data from the Centers for Disease Control and Prevention National Program for Cancer Registries and the National Cancer Institute Surveillance, Epidemiology, and End Results Program, we examined the geographic co-occurrence of mesothelioma and ovarian cancer incidence rates by U.S. state for 2003-2015. By state, mesothelioma incidence ranged from 0.5 to 1.3 cases per 100,000 persons and ovarian cancer incidence ranged from 9 to 12 cases per 100,000 females. When states were grouped by quartile of mesothelioma incidence, the average ovarian cancer incidence rate was 10% higher in states with the highest mesothelioma incidence than in states with the lowest mesothelioma incidence. Ovarian cancer incidence tended to be higher in states with high mesothelioma incidence (Pearson correlation = 0.54; < 0.0001). Data from state cancer registries show ovarian cancer incidence was positively correlated with mesothelioma incidence, suggesting asbestos may be a common exposure. The potential for asbestos exposure has declined since the 1970s because fewer products contain asbestos; however, some products, materials, and buildings may still release asbestos and thousands of workers may be exposed. Ensuring that people are protected from exposure to asbestos in their workplaces, homes, schools, and communities may reduce the risk of several cancers.
石棉是几种癌症的已确定病因，包括间皮瘤和卵巢癌。间皮瘤是与石棉相关的标志性癌症，其发病率因州而异，这可能反映了不同程度的石棉暴露。我们假设间皮瘤发病率高的州也可能有高的卵巢癌发病率。 利用美国疾病控制与预防中心国家癌症登记处和国家癌症研究所监测、流行病学和最终结果计划的数据，我们检查了 2003 年至 2015 年美国各州间皮瘤和卵巢癌发病率的地理共现情况。 按州划分，间皮瘤发病率范围为每 10 万人 0.5 至 1.3 例，卵巢癌发病率范围为每 10 万名女性 9 至 12 例。当各州按间皮瘤发病率的四分位数分组时，间皮瘤发病率最高的州的平均卵巢癌发病率比间皮瘤发病率最低的州高 10%。间皮瘤发病率高的州卵巢癌发病率较高（皮尔逊相关系数=0.54；<0.0001）。 州癌症登记处的数据表明，卵巢癌发病率与间皮瘤发病率呈正相关，表明石棉可能是一种常见的暴露因素。自 20 世纪 70 年代以来，由于含有石棉的产品减少，石棉暴露的可能性有所下降；然而，一些产品、材料和建筑物仍可能释放石棉，数千名工人可能接触到石棉。确保人们在工作场所、家庭、学校和社区免受石棉暴露，可能会降低几种癌症的风险。
