Ishida M, Ishizaki M, Yamada Y
Department of Hygiene, Kanazawa Medical University, Ishikawa, Japan.
Am J Ind Med. 1996 May;29(5):547-53. doi: 10.1002/(SICI)1097-0274(199605)29:5<547::AID-AJIM15>3.0.CO;2-0.
To elucidate the effect of low level lead (Pb) exposure on somatic and autonomic peripheral nerve functions in ceramic painters, 58 males and 70 females, aged 29-75 years (mean 53.3 years), with lead concentrations in blood (Pb-B) ranging from 2.1 to 69.5 micrograms/dl (geometric mean 13.3 micrograms/dl), were examined for median nerve maximal conduction velocity as a measure of motor nerve function, the coefficient of variation of R-R interval on electrocardiography as a measure of parasympathetic function, and postural changes in finger blood flow volume (delta FBF), and changes in finger blood flow drop velocity (FDV) from the supine to standing position as a measure of sympathetic function. No significant association was found between Pb-B levels and the results of the neurophysiological tests, however, except for that between Pb-B and delta FBF was decreased linearly with increasing Pb-B levels. However, this association could not be concluded to be a reflection of sympathetic nerve dysfunction due to Pb exposure in the subjects, since delta FBF was not a specific parameter of sympathetic nerve function. The possibility that the decrease in delta FBF is a reflection of the atherosclerotic effect of chronic low level Pb exposure should be further investigated.
为阐明低水平铅（Pb）暴露对陶瓷彩绘工人躯体和自主神经外周神经功能的影响，对58名男性和70名女性（年龄29 - 75岁，平均53.3岁）进行了检查，他们的血铅浓度（Pb - B）在2.1至69.5微克/分升之间（几何平均数为13.3微克/分升），检测指标包括：作为运动神经功能指标的正中神经最大传导速度、作为副交感神经功能指标的心电图R - R间期变异系数、手指血流量的姿势变化（delta FBF）以及从仰卧位到站立位手指血流下降速度（FDV）的变化作为交感神经功能指标。除了Pb - B与delta FBF之间呈线性下降关系（随着Pb - B水平升高delta FBF降低）外，未发现Pb - B水平与神经生理学测试结果之间存在显著关联。然而，由于delta FBF并非交感神经功能的特异性参数，因此不能得出这种关联反映了受试者因铅暴露导致交感神经功能障碍的结论。应进一步研究delta FBF降低是否反映慢性低水平铅暴露的动脉粥样硬化效应。
