Robinson D, Rainer R O, Washburn S A, Clarkson T B
Department of Obstetrics and Gynecology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27157, USA.
Neurourol Urodyn. 1996;15(3):215-21. doi: 10.1002/(SICI)1520-6777(1996)15:3<215::AID-NAU6>3.0.CO;2-I.
Menopause is presumed to have a causative role in the development of female urinary incontinence. While some clinical trials have shown that estrogen can affect urinary tract function, our knowledge of the pathophysiologic changes resulting from menopause and hormone replacement therapy is poor. The cynomolgus monkey is a well-established model for study of menopause and hormone replacement therapy, particularly in the cardiovascular arena. We have utilized this animal model to determine the histologic effects of estrogen and estrogen/progestin replacement therapy in the proximal urethra and vagina. Estrogen and estrogen/progestin replacement induced an increase in the amount of vaginal but not urethral epithelium. Hormone replacement also resulted in a significant increase in the loose, vascular component of the connective tissue layer of the urethra. The cynomolgus macaque shows promise as a useful model for further study of the effects of hormone replacement on the lower urinary tract.
更年期被认为在女性尿失禁的发生中起致病作用。虽然一些临床试验表明雌激素可影响尿路功能，但我们对更年期和激素替代疗法所导致的病理生理变化了解甚少。食蟹猴是研究更年期和激素替代疗法的成熟模型，尤其是在心血管领域。我们利用这个动物模型来确定雌激素和雌激素/孕激素替代疗法对尿道近端和阴道的组织学影响。雌激素和雌激素/孕激素替代疗法可使阴道上皮细胞数量增加，但尿道上皮细胞数量未增加。激素替代疗法还导致尿道结缔组织层中疏松的血管成分显著增加。食蟹猴有望成为进一步研究激素替代疗法对下尿路影响的有用模型。
