[弥漫性毒性甲状腺肿和甲状腺癌中的甲状腺结节：6例患者的经验]
[Thyroid nodule in Basedow-Graves disease and thyroid cancer: experience in 6 patients].
作者信息
Piraino P, Sepúlveda A, Ibarra A, Michelsen H, Gac A, Pumarino H
机构信息
Servicio de Anatomía Patológica y Servicio de Cirugía, Universidad de Chile, Santiago.
出版信息
Rev Med Chil. 1995 Nov;123(11):1402-8.
Traditionally, Basedow-Graves disease was considered a protection against thyroid cancer. However, recent reports suggest that cancer occurs with a higher frequency than expected and is more aggressive in this disease. We report six patients with hyperthyroidism due to a Basedow Graves disease that presented a palpable thyroid nodule, which was cold in the scintiscan and solid in the ultrasound examination. Fine needle cytology disclosed cancer in five cases (two with cytological features of greater aggressiveness) and a nodular hyperplasia in one. The diagnosis was confirmed in the surgical piece in all patients. We conclude that Basedow-Graves disease and thyroid cancer, which can have an increased aggressiveness, may coexist.
传统上，巴塞多-格雷夫斯病被认为可预防甲状腺癌。然而，最近的报告表明，在这种疾病中癌症发生的频率高于预期，且更具侵袭性。我们报告了6例因巴塞多-格雷夫斯病导致甲状腺功能亢进的患者，他们均出现了可触及的甲状腺结节，闪烁扫描显示为冷结节，超声检查显示为实性结节。细针穿刺细胞学检查在5例中发现癌症（2例具有更高侵袭性的细胞学特征），1例为结节性增生。所有患者的手术标本均证实了诊断。我们得出结论，巴塞多-格雷夫斯病和可能具有更高侵袭性的甲状腺癌可能共存。
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