Gaggero A, Escanilla D, Larrañaga C, Uribe P, Espejo R
Departamento de Microbiología, Universidad de Chile, Santiago.
Rev Med Chil. 1995 Oct;123(10):1189-98.
We studied the evolution of HIV-1 infection and immune response during six years in two twins born from an infected mother. The children had a continuous progression of the infection, proved by CD4+ cell count, serum anti-HIV antibodies, cultivable virus and proviral load. Now, both children are on antiviral treatment. The analysis of serum antibodies showed a different immune response in both children. One of them developed higher levels of antibodies directed against viral proteins and synthetic peptides derived from their aminoacid sequence. In this child, the amount of cultivable virus increased less than in his twin. Nucleotide sequencing of a part of viral genoma, showed that the virus belonged to the B subtype, prevalent in America and Europe. The observed differences in viral sequences suggest a different selective pressure in both twins. This phenomenon could be related to the observed differences in immune response.
我们研究了一名感染母亲所生的一对双胞胎在六年期间HIV-1感染及免疫反应的演变情况。通过CD4+细胞计数、血清抗HIV抗体、可培养病毒及前病毒载量证实，这两个孩子的感染呈持续进展。目前，两个孩子均在接受抗病毒治疗。血清抗体分析显示，两个孩子的免疫反应不同。其中一个孩子产生了针对病毒蛋白及源自其氨基酸序列的合成肽的更高水平抗体。在这个孩子体内，可培养病毒的数量增长低于其双胞胎。病毒基因组部分区域的核苷酸测序显示，该病毒属于在美国和欧洲流行的B亚型。观察到的病毒序列差异表明，两个双胞胎面临不同的选择压力。这种现象可能与观察到的免疫反应差异有关。
