Agren M S
Department of Pathology, Institute of Pathology and Forensic Medicine, Linköping, Sweden.
Br J Plast Surg. 1996 Mar;49(2):129-34. doi: 10.1016/s0007-1226(96)90088-0.
Alginate-based absorption materials for wound treatment are meeting with increasing clinical acceptance. The purpose of this study was to compare four different calcium alginate dressings (Algosteril, Comfeel Alginate, Kaltostat and Sorbsan) with respect to wound fluid retaining ability, adherence, dressing residues, epithelialisation and inflammatory cell infiltration using a standardised partial-thickness wound model in domestic pigs. Wound fluid spread laterally onto surrounding normal skin by about 40% more with Sorbsan than with the other alginate dressings after 24 h of treatment (P = 0.026). The corresponding figure after 66 h of treatment was 20% (P = 0.030). Algosteril (mean 1.7 [sem 0.3]) adhered significantly (P = 0.014) more to the wounds than Comfeel Alginate (mean 0.2 [0.2]). Kaltostat (mean 1.8 [0.3]) left significantly (P = 0.038) more dressing residues on the wound surface at dressing removal than the Comfeel Alginate dressing (mean 0.8 [0.2]). In the effect on epithelialisation or dermal inflammation there was no statistically significant difference at significance level 5% among the four alginate dressings, as assessed by light microscopy. In summary, the four alginate dressings showed significant differences in important handling characteristics and did not differ significantly in their effect on epithelialisation.
用于伤口治疗的藻酸盐基吸收材料正越来越受到临床认可。本研究的目的是使用标准化的家猪部分厚度伤口模型，比较四种不同的海藻酸钙敷料（Algosteril、Comfeel Alginate、Kaltostat和Sorbsan）在伤口液体保留能力、粘附性、敷料残留、上皮形成和炎性细胞浸润方面的差异。治疗24小时后，Sorbsan使伤口液体横向扩散到周围正常皮肤的程度比其他海藻酸钙敷料多约40%（P = 0.026）。治疗66小时后的相应数字为20%（P = 0.030）。Algosteril（平均值1.7[标准误0.3]）对伤口的粘附力显著（P = 0.014）高于Comfeel Alginate（平均值0.2[0.2]）。去除敷料时，Kaltostat（平均值1.8[0.3]）在伤口表面留下的敷料残留显著（P = 0.038）多于Comfeel Alginate敷料（平均值0.8[0.2]）。通过光学显微镜评估，在对上皮形成或真皮炎症的影响方面，四种海藻酸钙敷料在5%的显著性水平上没有统计学显著差异。总之，四种海藻酸钙敷料在重要的操作特性上表现出显著差异，而在对上皮形成的影响方面没有显著差异。
