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腔内氧对实验性肠系膜上动脉闭塞时内毒素吸收的影响。

Effect of intraluminal oxygen on endotoxin absorption in experimental occlusion of the superior mesenteric artery.

作者信息

Shute K

出版信息

Gut. 1977 Jul;18(7):567-70. doi: 10.1136/gut.18.7.567.

Abstract

Absorption of bacterial endotoxin has been shown to occur after release of the occluded superior mesenteric artery in the rat. A significant reduction in endotoxin absorption was observed as a result of the infusion of gaseous oxygen into the bowel lumen during the period of ischaemia (P less than 0-001). The methods of endotoxin identification and assay are described, and the possible reasons for this effect of intraluminal oxygen are discussed.

摘要

已表明大鼠肠系膜上动脉闭塞解除后会发生细菌内毒素吸收。在缺血期间向肠腔内注入气态氧后,观察到内毒素吸收显著减少(P小于0.001)。描述了内毒素鉴定和测定方法,并讨论了腔内氧气产生这种作用的可能原因。

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本文引用的文献

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Irreversible hemorrhagic shock in germfree rats.无菌大鼠的不可逆性失血性休克
J Exp Med. 1958 Mar 1;107(3):437-50. doi: 10.1084/jem.107.3.437.
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The lethal effect of endotoxins on the chick embryo.内毒素对鸡胚的致死作用。
J Exp Med. 1956 Aug 1;104(2):217-31. doi: 10.1084/jem.104.2.217.
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Experimental nonocclusive mesenteric ischemia. Physiologic and anatomic observations.
Arch Surg. 1968 Jun;96(6):987-94. doi: 10.1001/archsurg.1968.01330240133032.

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