Fleming C J, Hunt M J, Salisbury E L, McCarthy S W, Barnetson R S
Department of Dermatology, Royal Prince Alfred Hospital, New South Wales, Australia.
Br J Dermatol. 1996 Apr;134(4):784-7.
A 36-year-old man was treated with dapsone, rifampicin and clofazimine for borderline lepromatous leprosy. After 9 months, his leprosy plaques became progressively more red and after 23 months, the clofazimine was stopped and he was given minocycline instead. Six weeks later, he developed blue-black pigmentation in his leprosy lesions. The histology was consistent with minocycline-induced hyperpigmentation. This is the first report of minocycline-induced pigmentation in leprosy. We suggest it is important to consider this side-effect before the administration of minocycline in leprosy, particularly if it is prescribed in place of clofazimine.
一名36岁男性因边缘性瘤型麻风接受氨苯砜、利福平及氯法齐明治疗。9个月后，其麻风斑块颜色逐渐变红，23个月后停用氯法齐明，改用米诺环素。六周后，他的麻风皮损出现蓝黑色色素沉着。组织学检查结果与米诺环素引起的色素沉着相符。这是关于米诺环素引起麻风色素沉着的首例报告。我们建议，在麻风患者使用米诺环素前，尤其是在将其作为氯法齐明的替代药物处方时，考虑这种副作用很重要。
