图瓦儿童中各种基因标记与结核病及其他肺部疾病的关联
Association of various genetic markers with tuberculosis and other lung diseases in Tuvinian children.
作者信息
Pospelov L E, Matrakshin A G, Chernousova L N, Tsoi K N, Afanasjev K I, Rubtsova G A, Yeremeyev V V
机构信息
Central Research Institute for Tuberculosis, Moscow, Russia.
出版信息
Tuber Lung Dis. 1996 Feb;77(1):77-80. doi: 10.1016/s0962-8479(96)90080-5.
SETTING
Heredity factors influence susceptibility to tuberculosis and other lung diseases. Recent immunogenetic studies have confirmed the genetic predisposition to lung diseases in different populations. Precise knowledge of genetic aspects of disease susceptibility is important for improvement of public health.
OBJECTIVE
The aim of our research was to study the distribution of certain genetic markers in Tuvinian children suffering from tuberculosis and other lung diseases and to compare it with that in ethnically- and age-matched healthy donors. HLA-A, -B, -C and -DR antigens have been defined serologically by lymphocytotoxic assay, and variants of polymorphic protein loci Hp, Tf, Gc, ESD, ACP, PGM1, ADA, PGD have been defined by electrophoresis.
RESULTS
It was demonstrated that in Tuvinian children with tuberculosis the frequencies of HLA-DR2 and HLA-DRw53 antigens are increased in comparison with healthy donors. In children with non-tuberculous chronic lung diseases with allergic components the frequency of HLA-A1, -B5 and -B8 antigens and of genetic variants Hp2-2 and ESD1-1 was elevated.
CONCLUSION
HLA complex genetic factors influence susceptibility to tuberculosis and other lung diseases in Tuvinian children.
背景
遗传因素影响对结核病和其他肺部疾病的易感性。近期的免疫遗传学研究已证实不同人群中存在对肺部疾病的遗传易感性。精确了解疾病易感性的遗传方面对于改善公共卫生很重要。
目的
我们研究的目的是研究患有结核病和其他肺部疾病的图瓦儿童中某些遗传标记的分布，并将其与种族和年龄匹配的健康供体进行比较。通过淋巴细胞毒性试验血清学鉴定HLA - A、-B、-C和-DR抗原，通过电泳鉴定多态性蛋白质位点Hp、Tf、Gc、ESD、ACP、PGM1、ADA、PGD的变体。
结果
结果表明，与健康供体相比，患有结核病的图瓦儿童中HLA - DR2和HLA - DRw53抗原的频率增加。在患有伴有过敏成分的非结核性慢性肺部疾病的儿童中，HLA - A1、-B5和 - B8抗原以及遗传变体Hp2 - 2和ESD1 - 1的频率升高。
结论
HLA复合体遗传因素影响图瓦儿童对结核病和其他肺部疾病的易感性。
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