Stenfors L E, Räisänen S
Department of Otolaryngology, University Hospital of Tromsö, Norway.
J Laryngol Otol. 1996 Apr;110(4):339-42. doi: 10.1017/s0022215100133572.
Sequential bacterial samples were obtained from the tonsillar surface of 19 consecutive patients (12 females, seven males; mean age 16.1 years, range four to 24 years) suffering from infectious mononucleosis with membranous tonsillitis. The specimens were examined with respect to aerobes (culture on blood and chocolate agar plates) and proportions of bacteria coated with immunoglobulins (secretory IgA, IgG, IgM) by using an immunofluorescence assay. In the early stage of the membranous tonsillitis phase, attachment of secretory IgA (SIgA) and IgG to the bacteria was greatly suppressed, as compared with healthy controls. Coating with IgM was evident only late in the membranous tonsillitis phase but was contracted and still evident even after the clinical throat symptoms had abated. The findings suggest that the B-lymphotropic Epstein-Barr virus, causative agent of infectious mononucleosis, exerts a transient suppression of immunoglobulin-coating of bacteria harboured on the tonsillar surfaces, with consequent abundant bacterial attachment to the epithelial cells and massive bacterial colonization on the palatine tonsils.
从19例连续性患传染性单核细胞增多症合并膜性扁桃体炎的患者（12例女性，7例男性；平均年龄16.1岁，范围4至24岁）的扁桃体表面获取连续的细菌样本。通过需氧菌（在血琼脂平板和巧克力琼脂平板上培养）以及使用免疫荧光测定法检测覆盖有免疫球蛋白（分泌型IgA、IgG、IgM）的细菌比例来对样本进行检查。与健康对照相比，在膜性扁桃体炎阶段的早期，分泌型IgA（SIgA）和IgG与细菌的附着受到极大抑制。IgM覆盖仅在膜性扁桃体炎阶段后期才明显，但在临床咽喉症状消退后仍收缩且明显。这些发现表明，传染性单核细胞增多症的致病因子嗜B淋巴细胞的爱泼斯坦 - 巴尔病毒对扁桃体表面所携带细菌的免疫球蛋白覆盖产生短暂抑制，从而导致细菌大量附着于上皮细胞以及腭扁桃体上大量细菌定植。
